ULTRASENSITIVE ELECTROCHEMICAL SENSOR PLATFORM FOR MULTIPLEXED DETECTION OF MULTIPLE ANTI-SARS-CoV-2 IgG
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
; : 1487-1488, 2021.
Article
in English
| Scopus | ID: covidwho-2012716
ABSTRACT
The COVID-19 pandemic has demonstrated the need for better understanding of the kinetics of anti-SARSCoV-2 antibody production and development of serological assays for multiple viral antigens. Electrochemical (EC) sensor platforms offer the potential to develop rapid, sensitive, point-of-care (POC) diagnostics for this type of application. Here, we describe multiplexed EC biosensors with novel antifouling properties that detect anti-SARSCoV-2 immunoglobulin G (IgG) against spike protein (S), spike receptor-binding domain (RBD), and nucleocapsid (NC) antigens. This POC assay was validated using 69 clinical blood samples and obtained 96% sensitivity and 100% specificity with area under the curve (AUC) of 0.98 for multiplexed detection of anti-SARS-CoV-2 IgG. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
Antifouling; EC Biosensor; Multiplexed-serology; Point-of-care diagnostic; SARS-CoV-2; Antibodies; Antigens; Biosensors; Electrochemical biosensors; Anti-foulings; Antibody production; Antifouling property; Electrochemical biosensor; Immunoglobulin G; Multiplexed detection; Point of care diagnostic; Sensor platform; Ultrasensitive; Coronavirus
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Year:
2021
Document Type:
Article
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