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A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH.
Woller, Scott C; de Wit, Kerstin; Robert-Ebadi, Helia; Masias, Camila; Klok, Frederikus A; den Exter, Paul L; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John-Bjarne.
  • Woller SC; Department of Medicine Intermountain Medical Center, Intermountain Healthcare Murray Utah USA.
  • de Wit K; Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah USA.
  • Robert-Ebadi H; Departments of Emergency Medicine and Medicine Queen's University Kingston Ontario Canada.
  • Masias C; Departments of Medicine and HEI McMaster University Hamilton Ontario Canada.
  • Klok FA; Division of Angiology and Hemostasis Geneva University Hospitals and Faculty of Medicine Geneva Switzerland.
  • den Exter PL; Florida International University - Herbert Wertheim College of Medicine Miami Florida USA.
  • Morange PE; Department of Medicine - Thrombosis and Hemostasis Leiden University Medical Center Leiden The Netherlands.
  • Castelli D; Department of Medicine - Thrombosis and Hemostasis Leiden University Medical Center Leiden The Netherlands.
  • Hansen JB; Aix Marseille Univ Marseille France.
Res Pract Thromb Haemost ; 6(6): e12786, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2013781
ABSTRACT

Background:

Thrombosis is reported to occur more often among patients with COVID-19 than otherwise expected in the setting of viral pneumonia and sepsis. Systemic inflammatory biomarkers may be associated with venous thromboembolism (VTE) risk. The ISTH subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease aimed to report the evidence on prognostic biomarkers for VTE in hospitalized patients with COVID-19.

Methods:

Using a standardized Preferred Reporting Items for Systematic Reviews and Meta-analysis methodology, we conducted a systematic literature review to identify studies reporting prognostic biomarkers for VTE among hospitalized patients with COVID-19. Eligible studies included adults hospitalized with COVID-19 and reported the prognostic associations between any biomarker measured on admission, and the subsequent diagnosis of deep vein thrombosis or pulmonary embolism. Two authors reviewed titles and abstracts, and three authors extracted study data and performed review of bias. Results were displayed descriptively. Meta-analysis was not possible.

Results:

From the initial 196 identified studies, full-text review was performed for 72 studies. Admission D-dimer levels were associated with VTE during hospitalization in five studies, and elevated platelet count was associated with VTE during hospitalization in one study. The risk of bias ranged from low to high for included studies. Overall, there was a paucity of high-quality prognostic studies. Studies on other biomarkers did not meet the systematic review inclusion criteria.

Conclusions:

Admission D-dimer was associated with VTE diagnosis during hospitalization for COVID-19; however, prospective validation of this finding is needed to identify optimal D-dimer thresholds to guide VTE prophylaxis measures.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Res Pract Thromb Haemost Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Res Pract Thromb Haemost Year: 2022 Document Type: Article