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Phase separation in immune regulation and immune-related diseases.
Huang, Ning; Dong, Hao; Shao, Bin.
  • Huang N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases and State Key Laboratory of Biotherapy, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Dong H; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases and State Key Laboratory of Biotherapy, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Shao B; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases and State Key Laboratory of Biotherapy, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. sklbshaobin@scu.edu.cn.
J Mol Med (Berl) ; 100(10): 1427-1440, 2022 10.
Article in English | MEDLINE | ID: covidwho-2014078
ABSTRACT
Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade has provided mounting evidence that phase separation modulates a great variety of cellular activities. Particularly, phase separation is directly relevant to immune signaling, immune cells, and immune-related diseases like cancer, neurodegenerative diseases, and even SARS-CoV-2. In this review, we summarized current knowledge of phase separation in immunology and emerging findings related to immune responses as they enable possible treatment approaches.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Limits: Humans Language: English Journal: J Mol Med (Berl) Journal subject: Molecular Biology / Genetics, Medical Year: 2022 Document Type: Article Affiliation country: S00109-022-02253-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurodegenerative Diseases / COVID-19 Limits: Humans Language: English Journal: J Mol Med (Berl) Journal subject: Molecular Biology / Genetics, Medical Year: 2022 Document Type: Article Affiliation country: S00109-022-02253-9