Your browser doesn't support javascript.
Amyloidosis and COVID-19: experience from an amyloid program in Canada.
Lewis, Ellen; Fine, Nowell; Miller, Robert J H; Hahn, Christopher; Chhibber, Sameer; Mahe, Etienne; Tay, Jason; Duggan, Peter; McCulloch, Sylvia; Bahlis, Nizar; Neri, Paola; Jimenez-Zepeda, Victor H.
  • Lewis E; Division of Hematology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
  • Fine N; Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
  • Miller RJH; Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
  • Hahn C; Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Chhibber S; Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
  • Mahe E; Department of Pathology and Lab Medicine, University of Calgary, Calgary, AB, Canada.
  • Tay J; Division of Hematology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
  • Duggan P; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • McCulloch S; Charbonneau Cancer Research Institute, Calgary, AB, Canada.
  • Bahlis N; Division of Hematology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
  • Neri P; Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Jimenez-Zepeda VH; Division of Hematology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
Ann Hematol ; 101(10): 2307-2315, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2014115
ABSTRACT
Severe acute respiratory syndrome coronavirus (SARS-CoV2) and associated COVID-19 infection continue to impact patients globally. Patients with underlying health conditions are at heightened risk of adverse outcomes from COVID-19; however, research involving patients with rare health conditions remains scarce. The amyloidoses are a rare grouping of protein deposition diseases. Light-chain and transthyretin amyloidosis are the most common disease forms, often present with systemic involvement of vital organs including the heart, nerves, kidneys, and GI tracts of affected individuals. The Amyloidosis Program of Calgary examined 152 ATTR patients and 103 AL patients analyzing rates of vaccination, COVID-19 testing, infection outcomes, influence referrals, and excess deaths. Results showed 15 total PCR-confirmed COVID-19 infections in the tested population of amyloid patients, with a higher frequency of infections among patient with AL compared to the ATTR cohort (26.2% vs 5.1%). Four patients (26.6%) required hospital admission for COVID-19 infection, 2 ATTR, and 2 AL patients. Of the confirmed cases, 1 (0.07%) unvaccinated ATTR patient died of a COVID-19 infection. An excess of deaths was found in both the ATTR and AL cohorts when comparing pre-pandemic years 2018 and 2019 to the pandemic years of 2020 and 2021. The finding suggests that amyloidosis patients are likely at a high risk for severe COVID-19 infection and mortality, especially those of advanced age, those on an active treatment with chemotherapy, and those with concomitant B-cell or plasma cell disorder. The impact of virtual healthcare visits and pandemic measures on the excess of deaths observed requires further research.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Ann Hematol Journal subject: Hematology Year: 2022 Document Type: Article Affiliation country: S00277-022-04964-y

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Amyloid Neuropathies, Familial / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Ann Hematol Journal subject: Hematology Year: 2022 Document Type: Article Affiliation country: S00277-022-04964-y