Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing

ABSTRACT

Confronted with the global challenges including COVID-19, pharmaceutical manufacturing needs to simultaneously achieve long-term efficiency and short-term resilience. Process systems engineering (PSE) can provide scientific basis here, and in fact, PSE researchers have made significant contributions to pharma in the last decade. The author, after having worked for a global pharmaceutical company, initiated research on pharmaceutical process systems engineering Pharma PSE. The research tackles different challenges in small molecules, biopharmaceuticals, and regenerative medicine, at the scales of molecules/cells, processes, and the society. This paper first introduces the viewpoint of Pharma PSE, followed by showcasing a research example that involved a range of computer-aided analyses at different scales. The multiscale approach of Pharma PSE can provide a new horizon to “reimagine” pharmaceutical manufacturing processes and beyond, towards establishment of a sustainable healthcare society. © 2022 Elsevier B.V.