Your browser doesn't support javascript.
Antimicrobial peptides and their potential application in antiviral coating agents.
Freitas, Emanuelle D; Bataglioli, Rogério A; Oshodi, Josephine; Beppu, Marisa M.
  • Freitas ED; School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, São Paulo 13083-852, Brazil.
  • Bataglioli RA; School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, São Paulo 13083-852, Brazil.
  • Oshodi J; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
  • Beppu MM; School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, São Paulo 13083-852, Brazil. Electronic address: beppu@unicamp.br.
Colloids Surf B Biointerfaces ; 217: 112693, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-2015062
ABSTRACT
Coronavirus pandemic has evidenced the importance of creating bioactive materials to mitigate viral infections, especially in healthcare settings and public places. Advances in antiviral coatings have led to materials with impressive antiviral performance; however, their application may face health and environmental challenges. Bio-inspired antimicrobial peptides (AMPs) are suitable building blocks for antimicrobial coatings due to their versatile design, scalability, and environmentally friendly features. This review presents the advances and opportunities on the AMPs to create virucidal coatings. The review first describes the fundamental characteristics of peptide structure and synthesis, highlighting the recent findings on AMPs and the role of peptide structure (α-helix, ß-sheet, random, and cyclic peptides) on the virucidal mechanism. The following section presents the advances in AMPs coating on medical devices with a detailed description of the materials coated and the targeted pathogens. The use of peptides in vaccine formulations is also reported, emphasizing the molecular interaction of peptides with different viruses and the current clinical stage of each formulation. The role of several materials (metallic particles, inorganic materials, and synthetic polymers) in the design of antiviral coatings is also presented, discussing the advantages and the drawbacks of each material. The final section offers future directions and opportunities for using AMPs on antiviral coatings to prevent viral outbreaks.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Anti-Infective Agents Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Colloids Surf B Biointerfaces Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: J.colsurfb.2022.112693

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Anti-Infective Agents Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Journal: Colloids Surf B Biointerfaces Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: J.colsurfb.2022.112693