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Perceptions on Home-Administration of Biologics in the Context of Severe Asthma: An International Qualitative Study.
Flokstra-de Blok, Bertine; Kocks, Janwillem; Wouters, Hans; Arling, Chantal; Chatelier, Josh; Douglass, Jo; Heaney, Liam G; Holmes, Joshua; Humbert, Marc; Kolanowski, Mary; Landsman, Jeanet J A; Lugogo, Njira; Malpass, Alice; Meijer, Jiska; Metz, Boyd; de Mul, Bibicha; Postma, Frank; Leving, Marika.
  • Flokstra-de Blok B; General Practitioners Research Institute, Groningen, The Netherlands; Groningen Research Institute Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, University of Groningen
  • Kocks J; General Practitioners Research Institute, Groningen, The Netherlands; Groningen Research Institute Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Observational and Pragmatic Research Institute, Singapore, Singapore; Department of Pu
  • Wouters H; General Practitioners Research Institute, Groningen, The Netherlands.
  • Arling C; General Practitioners Research Institute, Groningen, The Netherlands.
  • Chatelier J; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
  • Douglass J; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
  • Heaney LG; Wellcome Wolfson Centre for Experimental Medicine, Queens University, Belfast, Northern Ireland.
  • Holmes J; Wellcome Wolfson Centre for Experimental Medicine, Queens University, Belfast, Northern Ireland.
  • Humbert M; Faculty of Medicine, Université Paris-Saclay, INSERM UMR_S 999, Assistance Publique - Hôpitaux de Paris, Department of Respiratory and Intensive Care Medicine, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
  • Kolanowski M; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich.
  • Landsman JJA; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Lugogo N; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich.
  • Malpass A; Bristol Medical School, Centre for Academic Primary Care (CAPC), University of Bristol, Bristol, UK.
  • Meijer J; General Practitioners Research Institute, Groningen, The Netherlands.
  • Metz B; General Practitioners Research Institute, Groningen, The Netherlands.
  • de Mul B; General Practitioners Research Institute, Groningen, The Netherlands.
  • Postma F; General Practitioners Research Institute, Groningen, The Netherlands.
  • Leving M; General Practitioners Research Institute, Groningen, The Netherlands.
J Allergy Clin Immunol Pract ; 10(9): 2312-2323.e2, 2022 09.
Article in English | MEDLINE | ID: covidwho-2015540
ABSTRACT

BACKGROUND:

Biologics are an effective therapy for severe asthma. Home administration of biologics by patients is likely to facilitate their accessibility. Yet little is known about patients' and health care providers' (HCPs) perceptions regarding home administration of biologics.

OBJECTIVE:

The aim of this study is to create more insight into the perceptions and experiences of patients and HCPs regarding home administration of biologics in the context of the treatment of severe asthma.

METHODS:

A qualitative international study was performed in the Netherlands, United States, Australia, and United Kingdom. In each country, 2 focus groups were held with potential/recent and long-term users of biologics at home. Prior to the focus groups, patients were prompted with themes on online forums. For triangulation purposes, interviews were held with HCPs to discuss salient findings from forums and focus groups. Data were analyzed with qualitative content analysis.

RESULTS:

In total, 75 patients participated in the forums, of which 40 participated in the focus groups. Furthermore, 12 HCPs were interviewed. The following overarching themes were identified living with severe asthma; practical aspects of using biologics; the role of HCPs regarding biologics; social support from family, friends, and others; effectiveness of biologics and other treatments; side effects of biologics.

CONCLUSIONS:

This study showed that, for those using biologics for severe asthma, the benefits of home administration of biologics usually outweigh inconvenience and side effects. Guided practice, accessible support contact, and monitoring including social support should be central in the transition from hospital to home administration of asthma biologics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Biological Products Type of study: Experimental Studies / Qualitative research / Randomized controlled trials Limits: Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Biological Products Type of study: Experimental Studies / Qualitative research / Randomized controlled trials Limits: Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2022 Document Type: Article