An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection.
Biotechnol Genet Eng Rev
; : 1-20, 2022 Sep 12.
Article
in English
| MEDLINE | ID: covidwho-2017140
ABSTRACT
Coronavirus disease 2019 (Covid-19) is a recent and current infectious pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Covid-19 may lead to the development of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and extrapulmonary manifestations in severe cases. Down-regulation of angiotensin-converting enzyme (ACE2) by the SARS-CoV-2 increases the production of angiotensin II (AngII), which increases the release of pro-inflammatory cytokines and placental growth factor (PlGF). PlGF is a critical molecule involved in vasculogenesis and angiogenesis. PlGF is stimulated by AngII in different inflammatory diseases through a variety of signaling pathways. PlGF and AngII are interacted in SARS-CoV-2 infection resulting in the production of pro-inflammatory cytokines and the development of Covid-19 complications. Both AngII and PlGF are interacted and are involved in the progression of inflammatory disorders; therefore, we aimed in this review to highlight the potential role of the PlGF/AngII axis in Covid-19.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Biotechnol Genet Eng Rev
Year:
2022
Document Type:
Article
Affiliation country:
02648725.2022.2122291
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