mRNA Vaccine-Elicited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells Persist at 6 Months and Recognize the Delta Variant.

Woldemeskel, Bezawit A; Garliss, Caroline C; Blankson, Joel N

Woldemeskel, Bezawit A; Garliss, Caroline C; Blankson, Joel N.

Woldemeskel BA; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Garliss CC; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Blankson JN; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Clin Infect Dis ; 75(1): e898-e901, 2022 Aug 24.

Article in English | MEDLINE | ID: covidwho-2017773

ABSTRACT

ABSTRACT

Little is known about the decay kinetics of coronavirus disease 2019 vaccine-elicited severe acute respiratory syndrome coronavirus 2-specific T cells. In this study we show a modest decline in the frequency of these T cells at 6 months and demonstrate robust expansion in response to antigen and recognition of spike peptides from the Delta variant.

Subject(s)

COVID-19; SARS-CoV-2; Antibodies, Viral; COVID-19/prevention & control; COVID-19 Vaccines; Humans; T-Lymphocytes; Vaccines, Synthetic; mRNA Vaccines

Keywords

COVID; Delta variant; SARS-CoV-2; T cells; mRNA vaccines

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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