Your browser doesn't support javascript.
Circulating Ubiquitous RNA, A Highly Predictive and Prognostic Biomarker in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients.
Bruneau, Thomas; Wack, Maxime; Poulet, Geoffroy; Robillard, Nicolas; Philippe, Aurélien; Puig, Pierre Laurent; Bélec, Laurent; Hadjadj, Jérôme; Xiao, Wenjin; Kallberg, Julia Linnea; Kernéis, Solen; Diehl, Jean Luc; Terrier, Benjamin; Smadja, David M; Taly, Valerie; Veyer, David; Péré, Hélène.
  • Bruneau T; Department of Microbiology, Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP.CUP) Hôpital Européen Georges Pompidou, Paris, France.
  • Wack M; Department of Medical Informatics, Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP.CUP) Hôpital Européen Georges Pompidou, Paris, France.
  • Poulet G; Centre de Recherche des Cordeliers, INSERM, Université Sorbonne Paris Cité, Université de Paris, Information Sciences to Support Medicine, Paris, France.
  • Robillard N; Centre de Recherche des Cordeliers, INSERM, CNRS, Université Sorbonne Paris Cité, Université de Paris, Equipe labellisée Ligue Nationale contre le cancer, CNRS SNC 5096, Paris, France.
  • Philippe A; Department of Microbiology, Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP.CUP) Hôpital Européen Georges Pompidou, Paris, France.
  • Puig PL; Hematology department, Assistance Publique Hôpitaux de Paris-Centre (AP-HP.CUP), Paris, France.
  • Bélec L; Université de Paris, Innovative Therapies in Hemostasis, INSERM, Paris, France Biosurgical Research Lab (Carpentier Foundation) European Georges Pompidou Hospital, Paris, France.
  • Hadjadj J; Centre de Recherche des Cordeliers, INSERM, CNRS, Université Sorbonne Paris Cité, Université de Paris, Equipe labellisée Ligue Nationale contre le cancer, CNRS SNC 5096, Paris, France.
  • Xiao W; Department of Microbiology, Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP.CUP) Hôpital Européen Georges Pompidou, Paris, France.
  • Kallberg JL; Université de Paris, INSERM U970, PARCC, Paris, France.
  • Kernéis S; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP CUP, Paris, France.
  • Diehl JL; Université de Paris, Institut Imagine, INSERM, Laboratory of Immunogenetics of Pediatric Autoimmuninity, Paris, France.
  • Terrier B; Centre de Recherche des Cordeliers, INSERM, CNRS, Université Sorbonne Paris Cité, Université de Paris, Equipe labellisée Ligue Nationale contre le cancer, CNRS SNC 5096, Paris, France.
  • Smadja DM; Centre de Recherche des Cordeliers, INSERM, CNRS, Université Sorbonne Paris Cité, Université de Paris, Equipe labellisée Ligue Nationale contre le cancer, CNRS SNC 5096, Paris, France.
  • Taly V; Equipe de Prévention du Risque Infectieux (EPRI), Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Paris, France.
  • Veyer D; Université de Paris, INSERM, IAME, Paris, France.
  • Péré H; Hematology department, Assistance Publique Hôpitaux de Paris-Centre (AP-HP.CUP), Paris, France.
Clin Infect Dis ; 75(1): e410-e417, 2022 08 24.
Article in English | MEDLINE | ID: covidwho-2017791
ABSTRACT

BACKGROUND:

Approximately 15-30% of hospitalized coronavirus disease 2019 (COVID-19) patients develop acute respiratory distress syndrome, systemic tissue injury, and/or multi-organ failure leading to death in around 45% of cases. There is a clear need for biomarkers that quantify tissue injury, predict clinical outcomes, and guide the clinical management of hospitalized COVID-19 patients.

METHODS:

We herein report the quantification by droplet-based digital polymerase chain reaction (ddPCR) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNAemia and the plasmatic release of a ubiquitous human intracellular marker, the ribonuclease P (RNase P) in order to evaluate tissue injury and cell lysis in the plasma of 139 COVID-19 hospitalized patients at admission.

RESULTS:

We confirmed that SARS-CoV-2 RNAemia was associated with clinical severity of COVID-19 patients. In addition, we showed that plasmatic RNase P RNAemia at admission was also highly correlated with disease severity (P < .001) and invasive mechanical ventilation status (P < .001) but not with pulmonary severity. Altogether, these results indicate a consequent cell lysis process in severe and critical patients but not systematically due to lung cell death. Finally, the plasmatic RNase P RNA value was also significantly associated with overall survival.

CONCLUSIONS:

Viral and ubiquitous blood biomarkers monitored by ddPCR could be useful for the clinical monitoring and the management of hospitalized COVID-19 patients. Moreover, these results could pave the way for new and more personalized circulating biomarkers in COVID-19, and more generally in infectious diseases, specific from each patient organ injury profile.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid