The Effect of Gestational Age at BNT162b2 mRNA Vaccination on Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Levels.
Clin Infect Dis
; 75(1): e603-e610, 2022 08 24.
Article
in English
| MEDLINE | ID: covidwho-2017834
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) during pregnancy and early infancy can result in severe disease. Evaluating the effect of gestational age at the time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on maternal antibody levels and transplacental antibody transfer has important implications for maternal care and vaccination strategies.METHODS:
Maternal and cord blood sera were collected from mother-newborn dyads (nâ =â 402), following term delivery after antenatal 2-dose SARS-CoV-2 BNT162b2 mRNA vaccination. SARS-CoV-2 spike protein (S) and receptor binding domain (RBD)-specific IgG levels were evaluated in the samples collected.RESULTS:
Median anti-S and anti-RBD-specific IgG levels in maternal sera at the time of delivery were lowest following first-trimester vaccination (nâ =â 90; anti-S IgG 76 AU/mL; anti-RBD-specific IgG 478 AU/mL), intermediate in those vaccinated in the second trimester (nâ =â 124; anti-S IgG 126 AU/mL; anti-RBD-specific IgG 1263 AU/mL), and highest after third-trimester vaccination (nâ =â 188; anti-S IgG 240 AU/mL; anti-RBD-specific IgG 5855 AU/mL). Antibody levels in neonatal sera followed a similar pattern and were lowest following antenatal vaccination in the first trimester (anti-S IgG 126 AU/mL; anti-RBD-specific IgG 1140 AU/mL). In a subgroup of parturients vaccinated in the first trimester (nâ =â 30), a third booster dose was associated with significantly higher maternal and neonatal antibody levels.CONCLUSIONS:
These results suggest a considerable antibody waning throughout pregnancy in those vaccinated at early gestation. The observed boosting effect of a third vaccine dose hints at its potential benefit in those who completed the 2-dose vaccine series at early pregnancy or before conception. The impact of antenatal immunization timing on SARS-CoV-2 transplacental antibody transfer may influence neonatal seroprotection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Viral Vaccines
/
COVID-19
Type of study:
Experimental Studies
Topics:
Vaccines
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Clin Infect Dis
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
Affiliation country:
Cid
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