"Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection".
QJM
; 2022 Sep 02.
Article
in English
| MEDLINE | ID: covidwho-2243544
ABSTRACT
OBJECTIVES:
This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalised COVID-19 adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).METHODS:
NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.RESULTS:
Analysis of 29,509 hospitalised, adult COVID-19 patients [mean (SD) age 51.1 (16.2) year; male 18752 (63.6%)] showed that 15678 (53.1%) had at least one comorbidity. Among 25715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age-group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy, and tuberculosis, presenting with dyspnea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI 4.6, 7.0)]. Patients receiving one [OR 0.5 (95% CI 0.4, 0.7)] or two doses of anti-SARS CoV-2 vaccine [OR 0.4 (95% CI 0.3, 0.7)] were protected from in-hospital mortality.CONCLUSIONS:
WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Topics:
Vaccines
Language:
English
Journal subject:
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Qjmed
Similar
MEDLINE
...
LILACS
LIS