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"Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection".
Mukherjee, Aparna; Kumar, Gunjan; Turuk, Alka; Bhalla, Ashish; Bingi, Thrilok Chander; Bhardwaj, Pankaj; Baruah, Tridip Dutta; Mukherjee, Subhasis; Talukdar, Arunansu; Ray, Yogiraj; John, Mary; Khambholja, Janakkumar R; Patel, Amit H; Bhuniya, Sourin; Joshi, Rajnish; Menon, Geetha R; Sahu, Damodar; Rao, Vishnu Vardhan; Bhargava, Balram; Panda, Samiran.
  • Mukherjee A; Indian Council of Medical Research, New Delhi, India.
  • Kumar G; Indian Council of Medical Research, New Delhi, India.
  • Turuk A; Indian Council of Medical Research, New Delhi, India.
  • Bhalla A; Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Bingi TC; Gandhi Medical College, Telangana, India.
  • Bhardwaj P; All Indian Institute of Medical Sciences, Jodhpur, Rajasthan, India.
  • Baruah TD; All Indian Institute of Medical Sciences, Raipur Chhattisgarh, India.
  • Mukherjee S; College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
  • Talukdar A; Medical College, Kolkata, West Bengal, India.
  • Ray Y; Infectious Disease And Beliaghata Hospital, Kolkata, West Bengal, India.
  • John M; Christian Medical College, Ludhiana, Punjab, India.
  • Khambholja JR; Smt. NHL, Municipal Medical College, Ahmedabad, Gujarat, India.
  • Patel AH; CIMS Hospital, Ahmedabad, India.
  • Bhuniya S; All India Institute Of Medical Sciences, Bhubaneswar, India.
  • Joshi R; All India Institute Of Medical Sciences, Bhopal, Madhya Pradesh, India.
  • Menon GR; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India.
  • Sahu D; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India.
  • Rao VV; National Institute of Medical Statistics, Indian Council of Medical Research, Delhi, India.
  • Bhargava B; Indian Council of Medical Research, New Delhi, India.
  • Panda S; Indian Council of Medical Research, New Delhi, India.
QJM ; 2022 Sep 02.
Article in English | MEDLINE | ID: covidwho-2243544
ABSTRACT

OBJECTIVES:

This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalised COVID-19 adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).

METHODS:

NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.

RESULTS:

Analysis of 29,509 hospitalised, adult COVID-19 patients [mean (SD) age 51.1 (16.2) year; male 18752 (63.6%)] showed that 15678 (53.1%) had at least one comorbidity. Among 25715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age-group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy, and tuberculosis, presenting with dyspnea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI 4.6, 7.0)]. Patients receiving one [OR 0.5 (95% CI 0.4, 0.7)] or two doses of anti-SARS CoV-2 vaccine [OR 0.4 (95% CI 0.3, 0.7)] were protected from in-hospital mortality.

CONCLUSIONS:

WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Qjmed

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Qjmed