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Clinical Impact and Risk Factors of Mortality in Hospitalized Children and Adolescents With Hematological Diseases and COVID-19: An Observational Retrospective Cohort Study.
Oliveira, Maria Christina L; Simões E Silva, Ana Cristina; Colosimo, Enrico A; Campos, Marcia K; Martelli-Júnior, Hercílio; Silva, Ludmila R; Pinhati, Clara C; Mak, Robert H; Oliveira, Eduardo A.
  • Oliveira MCL; Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine.
  • Simões E Silva AC; Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine.
  • Colosimo EA; Department of Statistics.
  • Campos MK; Division of Pediatric Hematology, Hospital das Clínicas.
  • Martelli-Júnior H; Health Science/Primary Care Postgraduate Program, State University of Montes Claros (Unimontes), Montes Claros.
  • Silva LR; Health Science/Postgraduate Program in Nursing. School of Nursing, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Pinhati CC; Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine.
  • Mak RH; Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, La Jolla, CA.
  • Oliveira EA; Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine.
J Pediatr Hematol Oncol ; 2022 Aug 30.
Article in English | MEDLINE | ID: covidwho-2274874
ABSTRACT
This study aimed to evaluate the risk factors for COVID-19-related death in a large cohort of hospitalized children with hematological disorders. We performed an analysis of all pediatric patients with COVID-19 registered in a Brazilian nationwide surveillance database between February 2020 and May 2021. The primary outcome was time to death, which was evaluated considering discharge as a competitive risk by using the cumulative incidence function. Among 21,591 hospitalized pediatric patients with COVID-19, 596 cases (2.8%) had hematological diseases. Sixty-one children (27.4%) with malignant hematological diseases had a fatal outcome as compared with 4.2% and 7.4% of nonmalignant hematological and nonhematological cohorts, respectively (P<0.0001). Children with hematological diseases had a significant increased hazard of death compared with those without these conditions (hazard ratio [HR],=2.40, 95% confidence interval, 1.98 - 2.91). In multivariable analysis, the factors associated with death were the presence of malignant hematological disease (HR, 2.22, 95% CI 1.47 - 3.36), age >10 years (HR 2.19, 95% CI 1.46 - 3.19), male (HR 1.52, 95% CI 1.02 - 2.27), oxygen saturation <95% (HR 2.02, 95% CI 1.38 - 2.96), and abdominal pain at admission (HR 2.75, 95% CI 1.76 - 4.27). Children with malignant hematological diseases had a higher risk of death compared with those without these disorders.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Hematology / Neoplasms / Pediatrics Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Hematology / Neoplasms / Pediatrics Year: 2022 Document Type: Article