Network-based Approach to Identify Pathways and Macromolecule Interactions that Mediate Influences of COVID-19 on the Progression of Respiratory System Diseases
2022 International Conference on Advancement in Electrical and Electronic Engineering, ICAEEE 2022
; 2022.
Article
in English
| Scopus | ID: covidwho-2018774
ABSTRACT
COVID-19 is an infectious illness concerning coronavirus that is transmitted through droplets propagated by an infected person exhales, coughs, or sneezes. People affected by coronavirus have a risk to occur respiratory diseases (RDs). The longevity of COVID-19 may appear a vital risk of manifesting RDs. To address these issues, we explored transcriptomic data to identify the genetic effects of COVID-19 on the development of RDs such as Bronchitis (BC), Asthma (AT), Lung cancer (LC), and Pulmonary Edema (PE). We explored GEO datasets from NCBI for COVID-19, BC, AT, LC, PE case, and control subjects. We identified COVID-19 is associated with RDs by sharing 16, 19, 27, and 59 commonly DEGs accordingly. By using these genes we performed some bioinformatics analysis and constructed diseasome networks, identified functional and ontological pathways. We formed PPIs networks and PDIs network. On the basis of PPIs and PDIs, we have identified hub proteins and constructed hub proteins network. We have successfully developed a quantitative model to identify the genetic effects of COVID-19 on the progression of RDs. We also validated our investigations through gold-benchmark datasets. Our results are an effective resource to mark out the most important influences on the development of RDs for COVID-19. © 2022 IEEE.
Asthma; Bronchitis; Comorbidities; Covid-19; Diseasome Network; Gene Enrichment; Lung cancer; Macromolecule Interactions; Pulmonary Edema; Respiratory System Diseases; Biological organs; Macromolecules; Proteins; Pulmonary diseases; Respiratory system; Bronchiti; Macromolecule interaction; Respiratory system disease; Genes
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Databases of international organizations
Database:
Scopus
Language:
English
Journal:
2022 International Conference on Advancement in Electrical and Electronic Engineering, ICAEEE 2022
Year:
2022
Document Type:
Article
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