Tom Nolan’s research reviews—1 September 2022

ABSTRACT

Unfortunately, the data used did not include patients on direct oral anticoagulants, which have largely replaced warfarin in the treatment of atrial fibrillation, meaning the conclusion that LAAO may be of most benefit to those with a high bleeding risk and low stroke risk is very much up for debate (Ann Intern Med doi10.7326/M21-4653). What is the sensitivity and clinical value of a low home oxygen saturation reading when over 20% of participants in all study arms reported hypoxaemia, yet so few required hospital admission? (N Engl J Med doi10.1056/NEJMoa2201662). [...]a linked editorial calls for more caution no evidence has been seen of hepatocellular adenoviral infection on histological examinations in these cases might the virus activity be an immunological response leading to acute hepatitis, or could adenovirus even be an “innocent bystander?” Better epidemiological data and registries of clinical studies are needed, it argues (NEJM doi10.1056/NEJMoa2206704;10.1056/NEJMoa2206294).