Time from symptom onset to severe COVID-19 and risk factors among patients in Southern Ethiopia: a survival analysis.
J Int Med Res
; 50(8): 3000605221119366, 2022 Aug.
Article
in English
| MEDLINE | ID: covidwho-2020829
ABSTRACT
OBJECTIVE:
This study aimed to assess the time to severe coronavirus disease 2019 (COVID-19) and risk factors among confirmed COVID-19 cases in Southern Ethiopia.METHOD:
This two-center retrospective cohort study involved patients with confirmed COVID-19 from 1 October 2020 to 30 September 2021. Kaplan-Meier graphs and log-rank tests were used to determine the pattern of COVID-19 severity among categories of variables. Bivariable and multivariable Cox proportional regression models were used to identify the risk factors of severe COVID-19.RESULTS:
Four hundred thirteen patients with COVID-19 with a mean age of 41.9 ± 15.3 years were involved in the study. There were 194 severe cases (46.9.1%), including 77 (39.6%) deaths. The median time from symptom onset to severe COVID-19 was 8 days (interquartile range 7-12 days). The risk factors for severe COVID-19 were age >65 (adjusted hazard ratio [AHR] = 2.65, 95% confidence interval [95%CI] 1.02, 3.72), cough (AHR = 1.59, 95%CI 1.39, 2.84), chest pain (AHR = 1.47, 95%CI 1.34, 2.66), headache (AHR = 2.04, 95%CI 1.43, 2.88), comorbidity (AHR = 1.3, 95%CI 1.01, 2.04), asthma (AHR = 1.6. 95%CI 1.04, 2.24), and symptom onset to admission more than 5 days (AHR = 0.48, 95%CI 0.34, 0.68).CONCLUSION:
Patients with symptoms and comorbidities should be closely monitored.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
/
Middle aged
Country/Region as subject:
Africa
Language:
English
Journal:
J Int Med Res
Year:
2022
Document Type:
Article
Affiliation country:
03000605221119366
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