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Time from symptom onset to severe COVID-19 and risk factors among patients in Southern Ethiopia: a survival analysis.
Sisay, Gizaw; Mantefardo, Bahru; Beyene, Aster.
  • Sisay G; Department of Public Health, College of Medicine and Health Sciences, Dilla University, Ethiopia.
  • Mantefardo B; Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, Dilla University, Ethiopia.
  • Beyene A; Department of Statistics, College of Natural and Computational Science, Dilla University, Ethiopia.
J Int Med Res ; 50(8): 3000605221119366, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2020829
ABSTRACT

OBJECTIVE:

This study aimed to assess the time to severe coronavirus disease 2019 (COVID-19) and risk factors among confirmed COVID-19 cases in Southern Ethiopia.

METHOD:

This two-center retrospective cohort study involved patients with confirmed COVID-19 from 1 October 2020 to 30 September 2021. Kaplan-Meier graphs and log-rank tests were used to determine the pattern of COVID-19 severity among categories of variables. Bivariable and multivariable Cox proportional regression models were used to identify the risk factors of severe COVID-19.

RESULTS:

Four hundred thirteen patients with COVID-19 with a mean age of 41.9 ± 15.3 years were involved in the study. There were 194 severe cases (46.9.1%), including 77 (39.6%) deaths. The median time from symptom onset to severe COVID-19 was 8 days (interquartile range 7-12 days). The risk factors for severe COVID-19 were age >65 (adjusted hazard ratio [AHR] = 2.65, 95% confidence interval [95%CI] 1.02, 3.72), cough (AHR = 1.59, 95%CI 1.39, 2.84), chest pain (AHR = 1.47, 95%CI 1.34, 2.66), headache (AHR = 2.04, 95%CI 1.43, 2.88), comorbidity (AHR = 1.3, 95%CI 1.01, 2.04), asthma (AHR = 1.6. 95%CI 1.04, 2.24), and symptom onset to admission more than 5 days (AHR = 0.48, 95%CI 0.34, 0.68).

CONCLUSION:

Patients with symptoms and comorbidities should be closely monitored.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Humans / Middle aged Country/Region as subject: Africa Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221119366

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Humans / Middle aged Country/Region as subject: Africa Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221119366