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Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives.
Soltani-Zangbar, Mohammad Sadegh; Parhizkar, Forough; Abdollahi, Mojtaba; Shomali, Navid; Aghebati-Maleki, Leili; Shahmohammadi Farid, Sima; Roshangar, Leila; Mahmoodpoor, Ata; Yousefi, Mehdi.
  • Soltani-Zangbar MS; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Parhizkar F; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Abdollahi M; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shomali N; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Aghebati-Maleki L; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shahmohammadi Farid S; School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Roshangar L; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mahmoodpoor A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Yousefi M; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Commun Signal ; 20(1): 131, 2022 08 29.
Article in English | MEDLINE | ID: covidwho-2021304
ABSTRACT
During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune mediators are involved in the dynamic interaction of ligands with membrane-bound receptors to maintain and restore health after pathological events. In some cases, the dysregulation of their expression can lead to disease pathology. In this literature review, we described current knowledge of the basic features of soluble immune mediators and their dysregulation during SARS-CoV-2 infections and highlighted their contribution to disease severity and mortality. Video Abstract.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Cell Commun Signal Year: 2022 Document Type: Article Affiliation country: S12964-022-00948-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Cell Commun Signal Year: 2022 Document Type: Article Affiliation country: S12964-022-00948-7