On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.
Hum Genomics
; 16(1): 33, 2022 08 26.
Article
in English
| MEDLINE | ID: covidwho-2021342
ABSTRACT
BACKGROUND:
The tripartite motif containing (TRIM)-22 participates in innate immune responses and exhibits antiviral activities. The present study aimed to assess of the relationship between TRIM22 single-nucleotide polymorphisms and clinical parameters with the coronavirus disease 2019 (COVID-19) infection severity.METHODS:
TRIM22 polymorphisms (rs7113258, rs7935564, and rs1063303) were genotyped using TaqMan polymerase chain reaction (PCR) assay in 495 dead and 497 improved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients.RESULTS:
In this study, the frequencies of TRIM22 rs1063303 GG, rs7935564 GG, and rs7113258 TT were significantly higher in dead patients than in improved patients, and higher viral load with low PCR Ct value was noticed in dead patients. The multivariate logistic regression analysis revealed that the lower levels of low-density lipoprotein (LDL), cholesterol, PCR Ct value, and lower 25-hydroxyvitamin D, and also higher levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and TRIM22 rs1063303 GG, rs7113258 TT, and rs3824949 GG genotypes were related to the COVID-19 infection severity.CONCLUSION:
Our finding proved the probable relationship between the COVID-19 infection severity with the genotypes of TRIM22 SNPs and clinical parameters. More research is required worldwide to show the association between the COVID-19 infection severity and host genetic factors.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Repressor Proteins
/
Minor Histocompatibility Antigens
/
Polymorphism, Single Nucleotide
/
Tripartite Motif Proteins
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Hum Genomics
Journal subject:
Genetics
Year:
2022
Document Type:
Article
Affiliation country:
S40246-022-00394-z
Similar
MEDLINE
...
LILACS
LIS