Utility of the Ratio between Lactate Dehydrogenase (LDH) Activity and Total Nucleated Cell Counts in Effusions (LDH/TNCC Ratio) for the Diagnosis of Feline Infectious Peritonitis (FIP).
Animals (Basel)
; 12(17)2022 Aug 31.
Article
in English
| MEDLINE | ID: covidwho-2023066
ABSTRACT
BACKGROUND:
We tested the hypothesis that the ratio between lactate dehydrogenase activity (LDH) and total nucleated cell counts (TNCC) in effusions may be useful to diagnose feline infectious peritonitis (FIP).METHODS:
LDH/TNCC ratio was retrospectively evaluated in 648 effusions grouped based on cytology and physicochemical analysis (step 1), on the probability of FIP estimated by additional tests on fluids (step 2) or on other biological samples (step 3, n = 471). Results of different steps were statistically compared. Receiver Operating Characteristic (ROC) curves were designed to assess whether the ratio identify the samples with FIP "probable/almost confirmed". The cut-offs with the highest positive likelihood ratio (LR+) or Youden Index (YI) or with equal sensitivity and specificity were determined.RESULTS:
A high median LDH/TNCC ratio was found in FIP effusions (step1 2.01) and with probable or almost confirmed FIP (step 2 1.99; 2.20 respectively; step 3 1.26; 2.30 respectively). The optimal cut-offs were 7.54 (LR+ 6.58), 0.62 (IY 0.67, sensitivity 89.1%; specificity 77.7%), 0.72 (sensitivity and specificity 79.2%) in step 2 and 2.27 (LR+ 10.39), 0.62 (IY 0.65, sensitivity 82.1%; specificity 83.0%), 0.54 (sensitivity 82.1%; specificity 81.9%) in step 3.CONCLUSIONS:
a high LDH/TNCC ratio support a FIP diagnosis.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Diagnostic study
/
Experimental Studies
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ani12172262
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