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New Aspects of the Antioxidant Activity of Glycyrrhizin Revealed by the CIDNP Technique.
Ageeva, Aleksandra A; Kruppa, Alexander I; Magin, Ilya M; Babenko, Simon V; Leshina, Tatyana V; Polyakov, Nikolay E.
  • Ageeva AA; Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
  • Kruppa AI; Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
  • Magin IM; Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
  • Babenko SV; Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
  • Leshina TV; International Tomography Center, 630090 Novosibirsk, Russia.
  • Polyakov NE; Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Antioxidants (Basel) ; 11(8)2022 Aug 17.
Article in English | MEDLINE | ID: covidwho-2023091
ABSTRACT
Electron transfer plays a crucial role in ROS generation in living systems. Molecular oxygen acts as the terminal electron acceptor in the respiratory chains of aerobic organisms. Two main mechanisms of antioxidant defense by exogenous antioxidants are usually considered. The first is the inhibition of ROS generation, and the second is the trapping of free radicals. In the present study, we have elucidated both these mechanisms of antioxidant activity of glycyrrhizin (GL), the main active component of licorice root, using the chemically induced dynamic nuclear polarization (CIDNP) technique. First, it was shown that GL is capable of capturing a solvated electron, thereby preventing its capture by molecular oxygen. Second, we studied the effect of glycyrrhizin on the behavior of free radicals generated by UV irradiation of xenobiotic, NSAID-naproxen in solution. The structure of the glycyrrhizin paramagnetic intermediates formed after the capture of a solvated electron was established from a photo-CIDNP study of the model system-the dianion of 5-sulfosalicylic acid and DFT calculations.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Antiox11081591

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2022 Document Type: Article Affiliation country: Antiox11081591