Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine
Applied Sciences
; 12(16):8262, 2022.
Article
in English
| ProQuest Central | ID: covidwho-2023100
ABSTRACT
Exosomal nanoparticles (exosomes or nanovesicles) are biogenic membrane vesicles secreted by various cell types and represent a conservative mechanism of intercellular and interspecies communication in pro- and eukaryotic organisms. By transporting specific proteins, nucleic acids, and low molecular weight metabolites, the exosomes are involved in the regulation of developmental processes, activation of the immune system, and the development of a protective response to stress. Recently, the plant nanovesicles, due to an economical and affordable source of their production, have attracted a lot of attention in the biomedical field. Being a natural transport system, the plant exosomes represent a promising platform in biomedicine for the delivery of molecules of both endogenous and exogenous origin. This review presents current data on the biogenesis of plant exosomes and their composition, as well as mechanisms of their loading with various therapeutic compounds, which are determining factors for their possible practical use. We believe that further research in this area will significantly expand the potential of targeted therapy, particularly targeted gene regulation via the small RNAs, due to the use of plant exosomes in clinical practice.
Sciences: Comprehensive Works; exosomes; targeted drug delivery; multivesicular bodies; membrane transport; Physiology; Plasma; Pathogens; Nucleic acids; Nanoparticles; Chemical compounds; Immune system; Low molecular weights; Biosynthesis; Gene regulation; Protein transport; Pharmacology; Membrane vesicles; Cell interactions; Metabolites; Lipids; Pharmaceuticals; Proteins; Vesicles; Mammals; Transportation systems; Molecular weight; Coronaviruses
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Applied Sciences
Year:
2022
Document Type:
Article
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