Your browser doesn't support javascript.
Post-COVID-19 depression and anxiety in patients with systemic lupus erythematosus.
Abd El-Khalik, Dina M; Eltohamy, Mohamed.
  • Abd El-Khalik DM; Department of Internal Medicine, Rheumatology Division, Ain Shams University Faculty of Medicine, Cairo, Egypt.
  • Eltohamy M; Department of Internal Medicine, Rheumatology Division, Armed Forces College of Medicine, Cairo, Egypt.
Lupus ; 32(8): 974-982, 2023 Jul.
Article in English | MEDLINE | ID: covidwho-20231677
ABSTRACT

OBJECTIVES:

This study aimed to evaluate depression and anxiety in patients with systemic lupus erythematosus (SLE) in the post-coronavirus disease-2019 (COVID-19) period and their potential association with the disease activity and related organ damage. PATIENTS AND

METHODS:

This is a case-control study including 120 adult Egyptian patients with SLE sixty patients with SLE who were proven previously to be positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by polymerase chain reaction (PCR) and recovered during the 3 months prior to the study were included in the case group and an equal number of age- and sex-matched patients with SLE and no evidence of SARS-CoV-2 infection were included in the control group. Patients' clinical history was collected, and they underwent clinical evaluation, including SLE disease activity, damage assessment, and psychological assessment.

RESULTS:

The mean depression and anxiety scores were significantly higher in cases than in the control group. Both scores showed a significant positive correlation with age, disease duration, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for SLE (SDI), and SLE disease activity index (SLEDAI) and a significant negative correlation with education years. Hierarchical multivariate regression analyses revealed that COVID-19 infection was a predictor for severe depression and moderate-to-severe anxiety.

CONCLUSIONS:

Patients with SLE, who are already vulnerable to physiological stressors, are especially predisposed to more risk of anxiety and depression when they are contracted with COVID-19 disease. Furthermore, anxiety and depression are associated with SLE activity and damage scores, and COVID-19 infection is a significant predictor for their severity. These results suggest that healthcare providers should give special attention to the mental health of SLE patients, especially during the COVID-19 pandemic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lupus Erythematosus, Systemic Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: Lupus Journal subject: Rheumatology Year: 2023 Document Type: Article Affiliation country: 09612033231181663

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lupus Erythematosus, Systemic Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: Lupus Journal subject: Rheumatology Year: 2023 Document Type: Article Affiliation country: 09612033231181663