Asthma in the elderly and COVID-19: results of the 90-day post-hospital follow-up.
Profilakticheskaya Meditsina
; 26(3):91-100, 2023.
Article
in Russian
| EMBASE | ID: covidwho-20232700
ABSTRACT
Background. After the first wave of the new SARS-CoV-2 coronavirus infection, the researchers focused on identifying potential short-and long-term complications of COVID-19, especially in high-risk patients, after prolonged hospitalization and intensive care. Objective. To study the outcomes, adverse effects of severe COVID-19 and their predictors 90 days after hospital discharge in elderly patients with asthma. Material and methods. The study included elderly patients (101 subjects, 42 males and 59 females;median age 74 (67;79) years) with asthma, discharged from the hospital after treatment of severe COVID-19. They were followed up for 90 days after discharge. In the hospital, COVID-19 was confirmed by laboratory tests (polymerase chain reaction method) and/or clinically and radiologically. All patients had a documented history of asthma according to GINA 2020 criteria. Results and discussion. During the 90-day post-hospital follow-up, 86 (85%) patients survived, and 15 (15%) died after discharge. Deaths were reported within 1 to 4 weeks after discharge 6 subjects died during re-hospitalization, 6 at home, and 3 in a rehabilitation center. The multivariate regression analysis model, adjusted for all statistically significant indicators, and the ROC analysis showed the most significant predictors of 90-day post-hospital mortality and their threshold values. They include the Charlson comorbidity index >=4 points, lung damage according to computed tomography >=30%, the absolute number of eosinophils <=100 cells/muL, and concomitant diabetes mellitus. The analysis showed that 90-day post-hospital mortality depends on combinations of identified risk factors;a combination of two, three, and especially four risk factors statistically significantly is associated with patients' lower average survival time. Conclusion. The key risk factors for 90-day post-hospital mortality in elderly patients with asthma after severe COVID-19 include the Charlson comorbidity index, lung damage >=30% according to computed tomography, the absolute number of eosinophils <=100 cells/muL, and concomitant diabetes mellitus. The 90-day post-hospital survival rate is correlated with the number of risk factors identified in patients. The effect of asthma severity on 90-day post-hospital mortality in elderly patients was not observed.Copyright © 2023, Media Sphera Publishing Group. All rights reserved.
90-day post-hospital period; asthma of the elderly; covid-19; mortality predictors; survival time; adverse event; aged; article; asthma; cause of death; Charlson Comorbidity Index; computer assisted tomography; controlled study; coronavirus disease 2019; diabetes mellitus; disease severity; eosinophil count; female; follow up; high risk patient; home care; hospital discharge; hospital mortality; hospital readmission; human; human cell; laboratory test; major clinical study; male; medical history; outcome assessment; polymerase chain reaction; radiodiagnosis; receiver operating characteristic; regression model; rehabilitation center; risk assessment; risk factor
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Prognostic study
Topics:
Long Covid
Language:
Russian
Journal:
Profilakticheskaya Meditsina
Year:
2023
Document Type:
Article
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