Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment.
J Korean Med Sci
; 38(22): e175, 2023 Jun 05.
Article
in English
| MEDLINE | ID: covidwho-20232782
ABSTRACT
Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Variants
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Journal:
J Korean Med Sci
Journal subject:
Medicine
Year:
2023
Document Type:
Article
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