[Translated article] Paradoxical interaction between nirmatrelvir/ritonavir and voriconazole in a patient with COVID-19.
Farm Hosp
; 47(2): T93-T95, 2023.
Article
in English, Spanish
| MEDLINE | ID: covidwho-20233036
ABSTRACT
This case is based on a drug interaction between nirmatrelvir/ritonavir (approved drug for COVID-19) and voriconazole is presented, possibly derived from the bidirectional effect of ritonavir on the 2 main voriconazole metabolizing enzymes (cytochrome P450 3A and 2C19) ritonavir inhibits the former and induces the latter respectively. According to the main pharmacotherapeutic information databases, in the interaction between both drugs, a decrease in the area under the curve of voriconazole is expected due to the inducing effect of its metabolism; however, in the case we present, unexpectedly, a paradoxical effect occurs, according to what is described in literature, with the result of sustained supratherapeutic levels of voriconazole. Given the short treatment period with nirmatrelvir/ritonavir (5â¯days), the induction effect of ritonavir proposed in the studies on which the recommendations are based, where treatment with ritonavir is longer, does not occur.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ritonavir
/
COVID-19
Type of study:
Case report
Limits:
Humans
Language:
English
/
Spanish
Journal:
Farm Hosp
Journal subject:
Pharmacy
/
Hospitals
Year:
2023
Document Type:
Article
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