THE IMPACT of PRIOR ANTITHROMBOTIC USE on THROMBOEMBOLIC EVENTS in PATIENTS with CARDIOVASCULAR DISEASE and SEVERE COVID-19 INFECTION
Cardiovascular Journal of Africa
; 33(Supplement):43-44, 2022.
Article
in English
| EMBASE | ID: covidwho-20233433
ABSTRACT
Objective:
Our objective in this study is to determine the predictive factors of thromboembolic complications in patients with previous heart disease and severe covid-19 infection and the impact of previous use of antithrombotic drugs on protection against these complications. Method(s) We conducted a single-center retrospective study of 158 patients with heart disease admitted to an intensive care unit for severe SARS-COV-2 infection. To determine the predictive factors, we used a logistic regression analysis. Result(s) Out of 158 patients, 22 were complicated by a thromboembolic event, i.e. 13.9%, mean age of our population was 64.03 (SD = 15.27), with a male predominance of 98 (62%), For the predictive factors of thromboembolic complications, and after multivariate analysis, we find the duration of hospitalization with (OR=0.92 ;95%CI (0.863 - 0.983), p=0.014, previous use of anti-thrombotic drugs as a protective factor with ( OR=0.288, 95%CI (0.091 - 0.911), p=0.034 for anti-platelet agents ) and ( OR=0, 322, 95%CI (0.131 - 0.851), p=0.021) for anti-coagulants (Figure1), and finally thrombocytopenia at admission as a risk factor ( OR=4.58 95%CI (1.2 - 10.627), p=0.021). D-dimer was not detected as a risk factor, and this can be explained by the characteristics of our population. Although the previous use of anti-thrombotic drugs protects against thrombo-embolic complications during severe infection, there was no benefit in terms of mortality (Figure2). Conclusion(s) Prior use of antithrombotic drugs is a protective factor against thromboembolic complications in patients with a history of heart disease but has no effect on mortality.
adult; cardiovascular disease; complication; conference abstract; controlled study; coronavirus disease 2019; drug therapy; heart disease; hospitalization; human; human cell; intensive care unit; major clinical study; male; mortality; retrospective study; risk factor; thrombocytopenia; thromboembolism; anticoagulant agent; antithrombocytic agent; D dimer
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Etiology study
/
Experimental Studies
/
Observational study
/
Prognostic study
Language:
English
Journal:
Cardiovascular Journal of Africa
Year:
2022
Document Type:
Article
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