Multifactorial Effects of Covid-19: A Review of Published Autopsy Reports
Journal of the American College of Surgeons
; 236(5 Supplement 3):S145, 2023.
Article
in English
| EMBASE | ID: covidwho-20234011
ABSTRACT
Introduction:
SARS-CoV-2 is responsible for the current global pandemic. SARS-CoV-2 infection underlies the novel viral condition coronavirus disease 2019 (COVID-19). COVID-19 causes significant pulmonary sequelae contributing to serious morbidities. The pathogenesis of COVID-19 is complex with a multitude of factors leading to varying levels of injury numerous extrapulmonary organs. This review of 124 published articles documenting COVID- 19 autopsies included 1,142 patients. Method(s) A PubMed search was conducted for COVID-19 autopsy reports published before March 2021 utilizing the query COVID-19 Autopsy. There was no restriction regarding age, sex, or ethnicity of the patients. Duplicate cases were excluded. Findings were listed by organ system from articles that met selection criteria. Result(s) Pulmonary pathology (72% of articles;866/1142 patients) diffuse alveolar damage (563/866), alveolar edema (251/866), hyaline membrane formation (234/866), type II pneumocyte hyperplasia (165/866), alveolar hemorrhage (164/866), and lymphocytic infiltrate (87/866). Vascular pathology (41% of articles;771/1142 patients) vascular thrombi (439/771)-microvascular predominance (294/439)-and inflammatory cell infiltrates (116/771). Cardiac pathology (41% of articles;502/1142 patients) cardiac inflammation (186/502), fibrosis (131/502), cardiomegaly (100/502), hypertrophy (100/502), and dilation (35/502). Hepatic pathology (33% of articles;407/1142 patients) steatosis (106/402) and congestion (102/402). Renal pathology (30% of articles;427/1142 patients) renal arteries arteriosclerosis (111/427), sepsis-associated acute kidney injury (81/427) and acute tubular necrosis (77/427). Conclusion(s) This review revealed anticipated pulmonary pathology, along with significant extrapulmonary involvement secondary to COVID-19, indicating widespread viral tropism throughout the human body. These diverse effects require additional comprehensive longitudinal studies to characterize short-term and long-term COVID-19 sequelae and inform COVID-19 treatment.
acute kidney tubule necrosis; adult; arteriosclerosis; autopsy; cardiomegaly; carditis; cell infiltration; complication; conference abstract; coronavirus disease 2019; diffuse alveolar damage; ethnicity; female; fibrosis; human; human cell; hyperplasia; hypertrophy; inflammatory cell; kidney disease; liver disease; longitudinal study; lung alveolus cell type 2; lung disease; lung edema; lung hemorrhage; lymphocytic infiltration; male; Medline; membrane formation; microvasculature; organ systems; renal artery; sepsis; steatosis; systematic review; thrombus; vascular disease; viral tropism; hyalin
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
Topics:
Long Covid
Language:
English
Journal:
Journal of the American College of Surgeons
Year:
2023
Document Type:
Article
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