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Impact of corticosteroids use on midterm sequelae in survivors of COVID-19 admitted to hospital: A prospective cohort study.
Gault, Nathalie; Bachelet, Delphine; Laouénan, Cédric; Borie, Raphaël; Cracowski, Claire; Poissy, Julien; Faure, Karine; Lainé, Fabrice; Lefèvre, Benjamin; Isnard, Margaux; Patrier, Juliette; Launay, Odile; Costagliola, Dominique; Ghosn, Jade; Bouadma, Lila.
  • Gault N; INSERM, Centre d'Investigations cliniques-Epidémiologie Clinique 1425, Hôpital Bichat, Paris, France.
  • Bachelet D; Département Epidémiologie Biostatistiques et Recherche Clinique, AP-HP.Nord Université Paris Cité, Hôpital Bichat, Paris, France.
  • Laouénan C; INSERM, Centre d'Investigations cliniques-Epidémiologie Clinique 1425, Hôpital Bichat, Paris, France.
  • Borie R; Département Epidémiologie Biostatistiques et Recherche Clinique, AP-HP.Nord Université Paris Cité, Hôpital Bichat, Paris, France.
  • Cracowski C; INSERM, Centre d'Investigations cliniques-Epidémiologie Clinique 1425, Hôpital Bichat, Paris, France.
  • Poissy J; Département Epidémiologie Biostatistiques et Recherche Clinique, AP-HP.Nord Université Paris Cité, Hôpital Bichat, Paris, France.
  • Faure K; INSERM, IAME UMR 1137, Université Paris Cité, Paris, France.
  • Lainé F; AP-HP, Service de Pneumologie, Hôpital Bichat, Paris, France.
  • Lefèvre B; INSERM CIC1406, Clinical Pharmacology Department, Grenoble Alpes University Hospital, Grenoble, France.
  • Isnard M; Université de Lille, Inserm U1285, CHU Lille, Pôle de réanimation, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, Lille, France.
  • Patrier J; Service de Maladies Infectieuses et Tropicales, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Université de Lille, Lille, France.
  • Launay O; CHU Rennes, INSERM CIC 1414, Rennes, France.
  • Costagliola D; CHRU Nancy, Infectious and Tropical Diseases, Université de Lorraine, Nancy, France.
  • Ghosn J; EA 4360 Apemac, Université de Lorraine, Nancy, France.
  • Bouadma L; Centre Hospitalier Métropole Savoie, service de Réanimation Polyvalente Adulte, Chambery, France.
J Med Virol ; 95(6): e28819, 2023 06.
Article in English | MEDLINE | ID: covidwho-20235863
ABSTRACT
An understanding of the midterm sequelae in COVID-19 and their association with corticosteroids use are needed. Between March and July 2020, we evaluated 1227 survivors of COVID-19, 3 months posthospitalization, of whom 213 had received corticosteroids within 7 days of admission. Main outcome was any midterm sequelae (oxygen therapy, shortness of breath, one major clinical sign, two minor clinical signs or three minor symptoms). Association between corticosteroids use and midterm sequelae was assessed using inverse propensity-score weighting models. Our sample included 753 (61%) male patients, and 512 (42%) were older than 65 years. We found a higher rate of sequelae among users than nonusers of corticosteroids (42% vs. 35%, odds ratio [OR] 1.40 [1.16-1.69]). Midterm sequelae were more frequent in users of low-dose corticosteroids than nonusers (64% vs. 51%, OR 1.60 [1.10-2.32]), whereas no association between higher doses (≥20 mg/day equivalent of dexamethasone) and sequelae was evidenced (OR 0.95 [0.56-1.61]). Higher risk of sequelae with corticosteroids use was observed among subjects with propensity score below the 90th percentile. Our study suggest that corticosteroids use during hospitalization for COVID-19 is associated with higher risk of midterm sequelae.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28819

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28819