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A New Neutralization Epitope in the Spike Protein of Porcine Epidemic Diarrhea Virus.
Liu, Jianbo; Shi, Hongyan; Chen, Jianfei; Zhang, Xin; Shi, Da; Ji, Zhaoyang; Jing, Zhaoyang; Feng, Li.
  • Liu J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Shi H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Chen J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Zhang X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Shi D; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Ji Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Jing Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
  • Feng L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, 678 Haping Road, Xiangfang District, Harbin 150069, China.
Int J Mol Sci ; 23(17)2022 Aug 26.
Article in English | MEDLINE | ID: covidwho-2023747
ABSTRACT
Porcine epidemic diarrhea virus (PEDV) infects piglets and causes serious diarrhea as well as vomiting, dehydration, and death. The trimeric S protein plays a crucial role in the induction of neutralizing antibodies, and many neutralizing monoclonal antibodies (mAbs) against PEDV S protein have been developed. However, these mAbs exclusively target the S1 protein. In this study, we obtained a neutralizing mAb, 5F7, against the S2 protein of PEDV, and this mAb could neutralize new variant genotype 2 PEDV strains (LNCT2), as well as a genotype 1 PEDV strain (CV777), in vitro. The core sequence of the epitope was found in amino acid sequence 1261 aa~1337 aa. These findings confirm that the S2 protein possessed neutralizing epitopes and provided knowledge to aid further research on this virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Porcine epidemic diarrhea virus Topics: Variants Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23179674

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Porcine epidemic diarrhea virus Topics: Variants Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23179674