Immunogenetic landscape of COVID-19 infections related neurological complications
COVID-19 in Alzheimer's Disease and Dementia
; : 133-146, 2023.
Article
in English
| Scopus | ID: covidwho-20237680
ABSTRACT
The human leukocyte antigen (HLA) is a critical component of antigen presentation and plays crucial role in conferring differential susceptibility and severity of diseases caused by viruses such as COVID-19. The immunogenetic profile of populations, BCG vaccination status, and a host of lifestyle factors might contribute to the observed variations in mortality rates due to COVID-19. These genetic, epigenetic, and environmental factors could widely influence infection dynamics and immune responses against COVID-19. The aim of this review is to provide an update on HLA association with SARS-CoV-2 infection in global populations and to highlight the possible neurological involvements. We also set out to explore the HLA immunogenetic markers related to COVID‐19 infections that can be used in screening high‐risk individuals for personalized therapies and in community-based vaccine development. © 2023 Elsevier Inc. All rights reserved.
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Type of study:
Prognostic study
Topics:
Vaccines
Language:
English
Journal:
COVID-19 in Alzheimer's Disease and Dementia
Year:
2023
Document Type:
Article
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