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Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy.
Sepúlveda, Claudia Soledad; García, Cybele Carina; Damonte, Elsa Beatriz.
  • Sepúlveda CS; Laboratory of Virology, Biochemistry Department, School of Sciences, University of Buenos Aires (UBA), Ciudad Universitaria, Buenos Aires 1428, Argentina.
  • García CC; Institute of Biochemistry of the School of Sciences (IQUIBICEN), CONICET-UBA, Ciudad Universitaria, Buenos Aires 1428, Argentina.
  • Damonte EB; Laboratory of Virology, Biochemistry Department, School of Sciences, University of Buenos Aires (UBA), Ciudad Universitaria, Buenos Aires 1428, Argentina.
Microorganisms ; 10(8)2022 Aug 12.
Article in English | MEDLINE | ID: covidwho-2023929
ABSTRACT
Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses presently lacking effective chemotherapy. HTA could provide a wide range of agents with inhibitory activity against current and future viruses that share similar host requirements and reduce the possible selection of antiviral-resistant variants. Nucleotide metabolism is one of the more exploited host metabolic pathways as a potential antiviral target for several human viruses. This review focuses on the antiviral properties of the inhibitors of pyrimidine and purine nucleotide biosynthesis, with an emphasis on the rate-limiting enzymes dihydroorotate dehydrogenase (DHODH) and inosine monophosphate dehydrogenase (IMPDH) for which there are old and new drugs active against a broad spectrum of pathogenic viruses.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10081631

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Reviews Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Microorganisms10081631