Frequency of antibiotic prescribing in adults hospitalized for SARS-CoV-2 in a high complexity institution in Santiago de Cali, Colombia.
Infectio
; 27(2):94-101, 2023.
Article
in Spanish
| EMBASE | ID: covidwho-20239633
ABSTRACT
Objective:
To determine the frequency of antibiotic use and to know which clinical and socio-demographic variables were related to the probability of suffering infections associated with COVID-19. Method(s) Adults hospitalized for COVID-19 who received one or more antibiotics during hospitalization were evaluated. We performed a descriptive analysis of variables in the general population' bivariate analysis in two groups (documented vs. suspected infection) and multivariate logistic regression of factors associated with mortality. Result(s) It was determined that 60.4% of adults hospitalized for COVID-19 received antibiotics. Coinfection was documented in 6.2% and superinfection in 23.3%. Gram-negative germs were reported in 75.8% of cultures, fungi in 17.8% and gram-positive in 14.2%. Variables such as age, comorbidities, ICU, anemia, steroids, mechanical ventilation, hemofiltration were statistically significantly related to documented infection. High-flow cannula was associated as a protective factor. Overall mortality was 43.9%, 57.8% in the first group and 38.1% in the second (p=0.002). Conclusion(s) There is a considerable frequency of antibiotic use in subjects hospitalized for COVID-19, particularly related to relevant findings of bacterial superinfection, in those with comorbidities, such as diabetes mellitus, immunosuppression, anemia and fragility, in whom the behavior of the disease is more severe and lethal.Copyright © 2023 Asociacion Colombiana de Infectologia. All rights reserved.
Antibacterial Agents; Coinfection; covid-19; Microbial Drug Resistance; SARS-CoV-2; Superinfection; adult; all cause mortality; anemia; antibiotic resistance; article; artificial ventilation; bacterial superinfection; bivariate analysis; Colombia; comorbidity; controlled study; coronavirus disease 2019; diabetes mellitus; Gram negative bacterium; hemofiltration; hospitalization; human; immunosuppressive treatment; mortality; nonhuman; prescription; Severe acute respiratory syndrome coronavirus 2; antibiotic agent; antiinfective agent; steroid; cannula
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Etiology study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Country/Region as subject:
South America
/
Colombia
Language:
Spanish
Journal:
Infectio
Year:
2023
Document Type:
Article
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