Should Young Covid-19 Patients be Suplemented with Vitamin D?
ARS Medica Tomitana
; 28(2):73-77, 2022.
Article
in English
| EMBASE | ID: covidwho-20240529
ABSTRACT
It is well known that vitamin D's general immunomodulatory actions are helpful in viral infections and that a shortage is linked to a more serious prognosis for Covid-19. In this sistematic review, we examined the existing literature on evidence as to whether there is also link between vitamin D range levels in pediatric population and the outcome of the Covid-19 infection. We looked for studies that measured vitamin D blood concentrations and examined the effects of vitamin D supplementation in young infected patients. Vitamin D may decrease the risk of respiratory infections in a number of ways through its interactions with numerous cells, including by decreasing viral survival and replication, reducing the cytokine storm, raising angiotensin-converting enzyme 2 concentrations (ACE2) while not damaging the endothelial integrity. The incidence or severity of Covid-19 is linked with blood 25-hydroxyvitamin D concentrations, according to many observational studies. However experimental verification is still needed. Given their safety and broad therapeutic window, vitamin D supplements seem to be an effective way for individuals and doctors to prevent or treat Covid-19. Nonetheless, the outcomes of significant vitamin D randomized controlled trials are further needed.Copyright © 2022 Maria Nicolae et al., published by Sciendo.
25-hydroxyvitamin D; Covid-19; vitamin D; adaptive immunity; article; calcium blood level; child; clinical outcome; coronavirus disease 2019/dt [Drug Therapy]; coronavirus disease 2019/pc [Prevention]; cytokine production; cytokine storm; drug safety; drug therapeutic index; human; immunomodulation; infection prevention; pediatric multisystem inflammatory syndrome; pneumonia; prescription; respiratory tract infection; risk factor; thorax radiography; virus replication; vitamin blood level; vitamin D deficiency/dt [Drug Therapy]; vitamin D metabolism; vitamin supplementation; 25 hydroxyvitamin D/dt [Drug Therapy]; 25 hydroxyvitamin D/pv [Special Situation for Pharmacovigilance]; angiotensin converting enzyme 2/ec [Endogenous Compound]; calcium/ec [Endogenous Compound]; cytokine/ec [Endogenous Compound]; parathyroid hormone/ec [Endogenous Compound]; phosphate/ec [Endogenous Compound]; vitamin D/ec [Endogenous Compound]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
ARS Medica Tomitana
Year:
2022
Document Type:
Article
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