Clinical and laboratory characteristics of SARS-CoV-2 infection in overweight and obese patients.
Infektsionnye Bolezni
; 20(4):5-11, 2022.
Article
in Russian
| EMBASE | ID: covidwho-20241279
ABSTRACT
Objective. To assess the impact of obesity and overweight on the course of COVID-19. Patients and methods. This prospective study included 218 patients with SARS-CoV-2 infection aged 18 to 94 years hospitalized between June 2020 and March 2021. We evaluated their clinical and laboratory parameters and their association with body weight. All patients were divided into 3 groups depending on their body mass index (BMI). Group 1 included 81 patients with grade 1-3 obesity (BMI >=30);group 2 comprised 71 overweight patients (BMI >=25 and <30);group 3 included 66 patients with normal body weight (BMI >=18.5 and <25). We analyzed clinical symptoms (including shortness of breath, fever, myalgia, headache, fatigue, changes in the oropharynx, cough, rhinorrhea, sore throat, anosmia, and diarrhea), prevalence of concomitant disorders and complications, findings of computed tomography and pulse oximetry, and findings of instrumental and laboratory examinations (complete blood count, urine test, electrocardiography, echo cardiography, biochemical assays, including C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, lactate, lactate dehydrogenase, activated partial thromboplastin time, prothrombin index, D-dimer, ferritin). Data analysis was performed using the Statistica 6.0 software. Results. We found that overweight and obese patients were more likely to have the main COVID-19 symptoms and comorbidities than those with normal weight. Overweight and obese patients also required respiratory support more frequently than patients with normal weight. Obese and overweight patients had more severe systemic inflammation (CRP, procalcitonin), cytolysis (ALT, AST), and thrombosis (D-dimer). Conclusion. Our findings suggest that obesity and overweight are the factors associated with a more severe SARS-CoV-2 infection, which should be considered when planning their treatment and developing resource strategies.Copyright © 2022, Dynasty Publishing House. All rights reserved.
covid-19; obesity; SARS-CoV-2; activated partial thromboplastin time; adult; aged; alanine aminotransferase blood level; anosmia; article; aspartate aminotransferase blood level; aspartate aminotransferase level; assisted ventilation; blood cell count; body mass; clinical evaluation; clinical feature; comorbidity; complication; computer assisted tomography; coronavirus disease 2019; coughing; diarrhea; disease course; dyspnea; echocardiography; electrocardiography; fatigue; female; ferritin blood level; fever; headache; hospital patient; human; inflammation; laboratory test; lactate blood level; lactate dehydrogenase blood level; major clinical study; male; myalgia; obese patient; oropharynx; prevalence; prospective study; pulse oximetry; rhinorrhea; sore throat; thrombosis; urinalysis; alanine aminotransferase/ec [Endogenous Compound]; aspartate aminotransferase/ec [Endogenous Compound]; C reactive protein/ec [Endogenous Compound]; D dimer/ec [Endogenous Compound]; ferritin/ec [Endogenous Compound]; lactate dehydrogenase/ec [Endogenous Compound]; lactic acid/ec [Endogenous Compound]; procalcitonin/ec [Endogenous Compound]; prothrombin/ec [Endogenous Compound]; data analysis software
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
Russian
Journal:
Infektsionnye Bolezni
Year:
2022
Document Type:
Article
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