Mechanism of interferon induction by cannabidiol (CBD) and analogues in lung cancer cells
Cancer Research Conference: American Association for Cancer Research Annual Meeting, ACCR
; 83(7 Supplement), 2023.
Article
in English
| EMBASE | ID: covidwho-20243306
ABSTRACT
CBD, an FDA approved drug for epilepsy, may have therapeutic potential for other diseases and is currently being tested for efficacy in cancer-related clinical trials. As the literature about CBD, especially in vitro reports, is often contradictory, increasing our understanding of its specific action on a molecular level will allow to determine whether CBD can become a useful therapy or exacerbates specific cancers in a context-dependent manner. Due to its relative lipophilicity, CBD is challenging to dispense at therapeutic concentrations;therefore, one goal is to identify cannabinoid congeners with greater efficacy and reduced drug delivery challenges. We recently showed that CBD activates interferons as a mechanism of inhibiting SARS-CoV-2 replication in lung carcinoma cells. As factors produced by the innate immune system, interferons have been implicated in both pro-survival and growth arrest and apoptosis signaling in cancer. Here we show that CBD induces interferon production and interferon stimulated genes (ISGs) through a mechanism involving NRF2 and MAVS in lung carcinoma cells. We also show that CBDV, which differs from CBD by 2 fewer aliphatic tail carbons, has limited potency, suggesting that CBD specifically interacts with one or more cellular proteins rather than having a non-specific effect. We also identified other CBD-related cannabinoids that are more effective at inducing ISGs. Taken together, these results characterize a novel mechanism by which CBD activates the innate immune system in lung cancer cells and identify related cannabinoids that have possible therapeutic potential in cancer treatment.
apoptosis; cancer model; cancer survival; cancer therapy; clinical trial; conference abstract; controlled study; drug delivery system; drug therapy; human; human cell; in vitro study; innate immunity; interferon induction; interferon production; lipophilicity; lung carcinoma; nonhuman; protein function; Severe acute respiratory syndrome coronavirus 2; signal transduction; cannabidiol; cannabinoid; cell protein; endogenous compound; interferon; transcription factor Nrf2
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Cancer Research Conference: American Association for Cancer Research Annual Meeting, ACCR
Year:
2023
Document Type:
Article
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