Your browser doesn't support javascript.
Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan.
Tani, Hideki; Inasaki, Noriko; Yazawa, Shunsuke; Shimada, Takahisa; Saga, Yumiko; Kaya, Hiroyasu; Maruyama, Yumiko; Matano, Sadaya; Itoh, Hiroyuki; Kashii, Tatsuhiko; Yamazaki, Emiko; Itamochi, Masae; Oishi, Kazunori.
  • Tani H; Department of Virology, Toyama Institute of Health, Japan.
  • Inasaki N; Department of Virology, Toyama Institute of Health, Japan.
  • Yazawa S; Department of Virology, Toyama Institute of Health, Japan.
  • Shimada T; Department of Virology, Toyama Institute of Health, Japan.
  • Saga Y; Department of Virology, Toyama Institute of Health, Japan.
  • Kaya H; Department of Infectious Diseases, Toyama Prefectural Central Hospital, Japan.
  • Maruyama Y; Department of Otolaryngology, Kurobe City Hospital, Japan.
  • Matano S; Infection Control Unit, Tonami General Hospital, Japan.
  • Itoh H; Takaoka City Hospital, Japan.
  • Kashii T; Toyama Rosai Hospital, Japan.
  • Yamazaki E; Department of Virology, Toyama Institute of Health, Japan.
  • Itamochi M; Department of Virology, Toyama Institute of Health, Japan.
  • Oishi K; Toyama Institute of Health, Japan.
Jpn J Infect Dis ; 2023 May 31.
Article in English | MEDLINE | ID: covidwho-20243619
ABSTRACT
Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has exploded owing to the emergence of various SARS-CoV-2 variants and has become a major problem at present. In this study, we analyzed the epidemiological information and possession status of neutralizing antibodies in patients with BI using SARS-CoV-2 pseudotyped viruses (SARS-CoV-2pv). Analysis of 44 specimens diagnosed with COVID-19 after two or more vaccinations showed high inhibition of infection by 90% or more against the Wuhan strain and the Alpha and Delta variants of pseudotyped viruses in 40 specimens. In contrast, almost no neutralizing activity was observed against the Omicron BA.1 variant. Many cases without neutralizing activity or BI were immunosuppressed individuals. The results of this study show that contact with an infected person can result in BI even when there are sufficient neutralizing antibodies in the blood. Thus, even after vaccination, sufficient precautions must be taken to prevent infection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Vaccines / Variants Language: English Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: Yoken.JJID.2023.100

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Vaccines / Variants Language: English Journal subject: Communicable Diseases Year: 2023 Document Type: Article Affiliation country: Yoken.JJID.2023.100