Update on nonpolio enterovirus and parechovirus infections in neonates and young infants.
Curr Opin Pediatr
; 35(3): 380-389, 2023 06 01.
Article
in English
| MEDLINE | ID: covidwho-20243856
ABSTRACT
PURPOSE OF REVIEW To review the epidemiology, clinical manifestations, and treatment strategies of nonpolio enterovirus and parechovirus (PeV) infections, and identify research gaps. RECENT FINDINGS:
There is currently no approved antiviral agent for enterovirus or PeV infections, although pocapavir may be provided on a compassionate basis. Elucidation of the structure and functional features of enterovirus and PeV may lead to novel therapeutic strategies, including vaccine development.SUMMARY:
Nonpolio human enterovirus and PeV are common childhood infections that are most severe among neonates and young infants. Although most infections are asymptomatic, severe disease resulting in substantial morbidity and mortality occurs worldwide and has been associated with local outbreaks. Long-term sequelae are not well understood but have been reported following neonatal infection of the central nervous system. The lack of antiviral treatment and effective vaccines highlight important knowledge gaps. Active surveillance ultimately may inform preventive strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Enterovirus
/
Picornaviridae Infections
/
Parechovirus
/
Enterovirus Infections
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Child
/
Humans
/
Infant
/
Infant, Newborn
Language:
English
Journal:
Curr Opin Pediatr
Journal subject:
Pediatrics
Year:
2023
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS