Temporal trends and determinants of COVID-19 vaccine series initiation after recent pregnancy.
Hum Vaccin Immunother
; 19(2): 2215150, 2023 08 01.
Article
in English
| MEDLINE | ID: covidwho-20243892
ABSTRACT
During the rapid deployment of COVID-19 vaccines in 2021, safety concerns may have led some pregnant individuals to postpone vaccination until after giving birth. This study aimed to describe temporal patterns and factors associated with COVID-19 vaccine series initiation after recent pregnancy in Ontario, Canada. Using the provincial birth registry linked with the COVID-19 vaccine database, we identified all individuals who gave birth between January 1 and December 31, 2021, and had not yet been vaccinated by the end of pregnancy, and followed them to June 30, 2022 (follow-up ranged from 6 to 18 months). We used cumulative incidence curves to describe COVID-19 vaccine initiation after pregnancy and assessed associations with sociodemographic, pregnancy-related, and health behavioral factors using Cox proportional hazards regression to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI). Among 137,198 individuals who gave birth in 2021, 87,376 (63.7%) remained unvaccinated at the end of pregnancy; of these, 65.0% initiated COVID-19 vaccination by June 30, 2022. Lower maternal age (<25 vs. 30-34 y aHR 0.73, 95%CI 0.70-0.77), smoking during pregnancy (vs. nonsmoking aHR 0.68, 95%CI 0.65-0.72), lower neighborhood income (lowest quintile vs. highest aHR 0.79, 95%CI 0.76-0.83), higher material deprivation (highest quintile vs. lowest aHR 0.74, 95%CI 0.70-0.79), and exclusive breastfeeding (vs. other feeding aHR 0.81, 95%CI 0.79-0.84) were associated with lower likelihood of vaccine initiation. Among unvaccinated individuals who gave birth in 2021, COVID-19 vaccine initiation after pregnancy reached 65% by June 30, 2022, suggesting persistent issues with vaccine hesitancy and/or access to vaccination in this population.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
North America
Language:
English
Journal:
Hum Vaccin Immunother
Year:
2023
Document Type:
Article
Affiliation country:
21645515.2023.2215150
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