Findings from the ECHO Cohorts Regarding the Effects of the COVID-19 Pandemic
Birth Defects Research
; 115(8):844, 2023.
Article
in English
| EMBASE | ID: covidwho-20243926
ABSTRACT
Background:
Studies suggest perinatal infection with SARSCoV- 2 can induce adverse birth outcomes, but studies published to date have substantial limitations. Most have identified cases based upon their presentation for clinical care, and very few have examined pandemic-related stress which may also impact adverse birth outcomes. Objective(s) To evaluate the relationships between SARSCoV- 2 infection in pregnancy and pandemic-related stress with birth outcomes. StudyDesign:
We conducted an observational study of 211 mother-newborn dyads in three urban cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) Program. Serology for SARS-CoV-2 was assessed in a convenience sample of prenatal maternal, cord serum or dried blood spots from births occurring between January 2020-September 2021. Specimens were assessed for IgG, IgM, and IgA antibodies to nucleocapsid, S1 spike, S2 spike, and receptor-binding domain. A Pandemic-related Traumatic Stress (PTS) scale was based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition Acute Stress Disorder criteria. Result(s) 36% were positive for at least one antibody type, chiefly IgG. Self-report of infection was not significantly correlated with combined serology. There were no differences in gestational age (GA), birth weight, preterm birth (PTB), or low birth weight (LBW) among seropositive mothers. However, IgM seropositive mothers had children with lower BW (434g, 95% CI 116- 752), BW Z score-for-GA (0.73 SD, 95% CI 0.10-1.36) and were more likely to deliver preterm (OR 8.75, 95% CI 1.22-62.4). Associations with LBW sustained in sensitivity analyses limited to pre-vaccine samples, and PTS symptoms were not associated with birth outcomes. The addition of PTS did not substantially change associations with BW, although associations with PTB attenuated to near-significance. Conclusion(s) We identified decreased birth weight and increased prematurity in mothers IgM seropositive to SARS-CoV-2, independent of PTS. Though there are limits to interpretation, the data support efforts to prevent SARS-CoV-2 infections in pregnancy.
acute stress disorder; birth weight; child; child health; conference abstract; controlled study; convenience sample; cord serum; coronavirus disease 2019; dsm-5; female; gestational age; human; human tissue; low birth weight; major clinical study; maternal serum; mother; newborn; nonhuman; observational study; outcome assessment; pandemic; posttraumatic stress disorder; pregnancy; pregnancy outcome; prematurity; receptor binding; self report; sensitivity analysis; serology; Severe acute respiratory syndrome coronavirus 2; spike; virus nucleocapsid; endogenous compound; immunoglobulin A antibody; immunoglobulin G; immunoglobulin M; vaccine
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Language:
English
Journal:
Birth Defects Research
Year:
2023
Document Type:
Article
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