The interplay between viral molecular mimicry and host chromatin dynamics.
Nucleus
; 14(1): 2216560, 2023 12.
Article
in English
| MEDLINE | ID: covidwho-20244882
ABSTRACT
Molecular mimicry is a commonly used mechanism by viruses to manipulate host cellular machinery and coordinate their life cycles. While histone mimicry is well studied, viruses also employ other mimicry strategies to affect chromatin dynamics. However, the relationship between viral molecular mimicry and host chromatin regulation is not well understood. This review summarizes recent advances in histone mimicry and explores how viral molecular mimicry influences chromatin dynamics. We also discuss how viral proteins interact with both intact and partially unfolded nucleosomes and compare the distinct mechanisms governing chromatin tethering. Finally, we address the role of viral molecular mimicry in regulating chromatin dynamics. This review provides new insights into viral molecular mimicry and its impact on host chromatin dynamics, paving the way for the development of novel antiviral strategies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viruses
/
Chromatin
Language:
English
Journal:
Nucleus
Year:
2023
Document Type:
Article
Affiliation country:
19491034.2023.2216560
Similar
MEDLINE
...
LILACS
LIS