COVID-19 during the Third Semester of Pregnancy: Maternal Characteristic, Possibility of Intrauterine Transmission and Neonatal Outcome in Aceh, Indonesia
Open Access Macedonian Journal of Medical Sciences
; 11(B):293-298, 2023.
Article
in English
| EMBASE | ID: covidwho-20245045
ABSTRACT
BACKGROUND:
Pregnant women are vulnerable against COVID-19 infection due to physiological and immunological changes. COVID-19 in pregnancy affects fetal well-being with a potential for vertical infection.AIM:
This study aims to determine the incidence of vertical infection and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in infants born to mothers with positive COVID-19 infection. MATERIALS ANDMETHODS:
Amniotic fluid, swabs of the newborn's nasopharynx and oropharynx, and swabs of the placenta were examined using reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Serological examination was performed by Electro-Chemiluminescence Immunoassay on infant's blood. RESULT(S) Four of 33 pregnant women gave birth to infants positive SARS-CoV-2 infection. RT-PCR examination of all amniotic fluid and placental swabs was negative for SARS-CoV-2. Four of 33 infants (12.1%) showed negative polymerase chain reaction (PCR) results but positive SARS-CoV-2 antibodies, another 4 newborns (12.1%) showed positive PCR results, but no SARS-CoV-2 antibodies detected. The remaining 25 babies (75.8%) showed both negative PCR and serologic results. CONCLUSION(S) No evidence of vertical transmission found in this study.Copyright © 2023 Cut Meurah Yeni, Zinatul Hayati, Sarjani M. Ali, Hasanuddin Hasanuddin, Rusnaidi Rusnaidi, Cut Rika Maharani.
Anti-SAR-CoV-2 antibody; covid-19; Pregnancy; Vertical infection; Aceh; adult; amnion fluid; article; clinical article; controlled study; coronavirus disease 2019; electrochemiluminescence immunoassay; female; gene amplification; human; incidence; infant; mother; nasopharynx; newborn; nonhuman; oropharynx; placenta; pregnant woman; reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; vertical transmission; SARS-CoV-2 antibody
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Open Access Macedonian Journal of Medical Sciences
Year:
2023
Document Type:
Article
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