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COVID-19 Severity and Mortality Among Chronic Liver Disease Patients: A Systematic Review and Meta-Analysis.
Nagarajan, Ramya; Krishnamoorthy, Yuvaraj; Rajaa, Sathish; Hariharan, Vishnu Shankar.
  • Nagarajan R; Indian Council of Medical Research, National Institute of Epidemiology, Chennai, India. Email: nagarajanramya55@gmail.com.
  • Krishnamoorthy Y; Department of Community Medicine, ESIC Medical College and PGIMSR, K.K. Nagar, Chennai, Tamil Nadu, India.
  • Rajaa S; Department of Community Medicine, ESIC Medical College and PGIMSR, K.K. Nagar, Chennai, Tamil Nadu, India.
  • Hariharan VS; Department of General Medicine, Hindu Mission Hospital, Chennai, Tamil Nadu, India.
Prev Chronic Dis ; 19: E53, 2022 08 25.
Article in English | MEDLINE | ID: covidwho-2025235
ABSTRACT

INTRODUCTION:

Pre-existing comorbid conditions in COVID-19 patients are risk factors for developing severe disease and death. We aimed to determine the association of chronic liver disease (CLD), a comorbid condition, with severity of disease and death among COVID-19 patients.

METHODS:

We searched for studies reporting COVID-19 outcomes among CLD and non-CLD patients in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception of the pandemic until February 2022. Risk of bias assessment was conducted by using the Newcastle-Ottawa Scale for assessing the quality of nonrandomized studies in meta-analyses. We conducted a meta-analysis with a random-effects model and reported pooled odds ratios (ORs) with 95% CIs.

RESULTS:

We included 40 studies with 908,032 participants. Most studies were conducted in China and the US. COVID-19 patients with CLD had significantly higher odds of having a severe form of COVID-19 (pooled OR = 2.44; 95% CI, 1.89-3.16) and death (pooled OR = 2.35; 95% CI, 1.85-3.00) when compared with COVID-19 patients without CLD.

CONCLUSION:

The presence of CLD is significantly related to adverse clinical outcomes among COVID-19 patients in terms of severity and mortality. Clinicians should develop a comprehensive intervention plan to manage these high-risk patients and reduce COVID-19-related deaths.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Prev Chronic Dis Journal subject: Public Health Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Prev Chronic Dis Journal subject: Public Health Year: 2022 Document Type: Article