Effects of different mucosal adjuvants on the immune responses induced by porcine deltacoronavirus in mice
Acta Microbiologica Sinica
; 7(23), 2022.
Article
in Chinese
| CAB Abstracts | ID: covidwho-2025659
ABSTRACT
Objective:
The aim of this study is to screen an ideal adjuvant for an inactivated porcine deltacoronavirus(PDCoV) vaccine to induce mucosal immunity and reduce the side effect of the vaccine. We used different mucosal adjuvants to prepare the inactivated PDCoV vaccines. We then used mouse model to evaluate the humoral, cellular and mucosal immune responses induced by the inactivated vaccines via different immunization routes.
Host Resistance and Immunity [HH600]; Laboratory Animal Science [LL040]; Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821]; Animal Immunology [LL650]; animal models; laboratory animals; adjuvants; immune response; IgG; immunization; vaccines; gene expression; interleukin 4; vaccine development; disease prevention; disease control; mucosa; immunity; ELISA; interferon-gamma; inactivated vaccines; immune sensitization; mice; Porcine deltacoronavirus; Muridae; rodents; mammals; vertebrates; Chordata; animals; eukaryotes; Deltacoronavirus; Orthocoronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; immunity reactions; immunological reactions; mucous membrane; enzyme linked immunosorbent assay; killed vaccines
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
Chinese
Journal:
Acta Microbiologica Sinica
Year:
2022
Document Type:
Article
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