Analysis of intermediate hosts and susceptible animals of SARS-CoV-2 by computational methods
Zoonoses
; 1(6), 2021.
Article
in English
| CAB Abstracts | ID: covidwho-2025742
ABSTRACT
COVID-19, a disease caused by SARS-CoV-2 that produces major symptoms of pneumonia, has been a disaster worldwide. The traceability of SARSCoV- 2 and the discovery of susceptible animal species is crucial to halt viral transmission and explore the mechanism of cross-species transmission. We selected 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the hACE2 protein. All selected ACE2 proteins were subjected to homology modeling. Potential natural and intermediate hosts, as well as animal species susceptible to SARS-CoV-2, were analyzed systematically by calculation of the binding free energy of ACE2 protein to the RBD of SARSCoV- 2. Primates, some wild Felidae, civets, goats, spotted hyenas and golden hamsters are susceptible to SARS-CoV-2 and may be potential intermediate hosts, whereas pangolins, birds and reptiles are unlikely to be intermediate hosts. Mice, rats and guinea pig are not susceptible to SARS-CoV-2. Given their possible susceptibility, non-human primates, goats and golden hamsters could potentially be used as experimental models to examine SARS-CoV-2 infection without transgenesis. Herein, possible candidates for the natural and intermediate hosts of SARS-CoV-2 are suggested, to provide guidance for subsequent studies.
Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Animal Models of Human Diseases [VV400]; Pathogens, Parasites and Infectious Diseases (Wild Animals) [YY700]; coronavirus disease 2019; disease models; disease transmission; domestic animals; human diseases; intermediate hosts; livestock; pandemics; reservoir hosts; susceptibility; viral diseases; wild animals; wildlife conservation; zoonoses; hosts; birds; Crocuta crocuta; Felidae; goats; golden hamsters; guineapigs; man; Manis; mice; primates; rats; reptiles; Severe acute respiratory syndrome coronavirus 2; Viverridae; vertebrates; Chordata; animals; eukaryotes; Crocuta; Hyaenidae; Fissipeda; carnivores; mammals; Capra; Bovidae; ruminants; Artiodactyla; Mesocricetus; Cricetinae; Muridae; rodents; Cavia; Caviidae; Homo; Hominidae; Manidae; Pholidota (Mammalia); Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; guinea pigs; secondary hosts; animal reservoirs; SARS-CoV-2; viral infections; zoonotic infections
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
English
Journal:
Zoonoses
Year:
2021
Document Type:
Article
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