Advances in acute severe hepatitis of unknown etiology in children
Zoonoses
; 2(19), 2022.
Article
in English
| CAB Abstracts | ID: covidwho-2025752
ABSTRACT
Since the International Health Regulations National Focal Point for the United Kingdom alerted the WHO of ten cases of acute severe hepatitis of unknown etiology in children on April 5, 2022, relevant cases have been reported worldwide. These patients had acute hepatitis (negative for hepatitis viruses A-E) and elevated aminotransferase (AST) or alanine aminase (ALT) exceeding 500 U/L. Furthermore, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and/or adenovirus type F41 have been detected in some cases. This unknown hepatitis has been hypothesized to be induced by a viral reservoir of novel coronavirus superantigen, which repeatedly stimulates the intestines and leads to a multisystem inflammatory syndrome in children (MIS-C), which causes immune abnormalities in the presence of human adenovirus. Although this hypothesis has not been confirmed by any in vivo experimental or clinical studies, it may provide ideas for possible intervention strategies.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Human Immunology and Allergology [VV055]; acute course; severe course; human diseases; hepatitis A; viral hepatitis; liver; liver diseases; hepatitis B; hepatitis C; hepatitis D; hepatitis E; inflammation; children; alanine aminotransferase; aminotransferases; aetiology; intestines; man; Hepatovirus A; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Hepatitis E virus; Adenoviridae; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Hepatovirus; Picornaviridae; Picornavirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Orthohepadnavirus; Hepadnaviridae; DNA Reverse Transcribing Viruses; Hepacivirus; Flaviviridae; Deltavirus; negative-sense ssRNA Viruses; Hepevirus; Hepeviridae; dsDNA Viruses; DNA Viruses; glutamate pyruvate transaminase; glutamic pyruvic transaminase; GPT; transaminases; causal agents; etiology
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Etiology study
Language:
English
Journal:
Zoonoses
Year:
2022
Document Type:
Article
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