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[The role of systemic ozone therapy in the rehabilitation of patients after COVID-19]. / Rol' sistemnoi ozonoterapii v reabilitatsii patsientov, perenesshikh COVID-19.
Tsvetkova, A V; Koneva, E S; Kostenko, A A; Bisheva, D R; Sidyakina, I V; Konev, S M; Zhumanova, E N; Illarionov, V E; Shestakov, A V.
  • Tsvetkova AV; Sechenov First Moscow State Medical University, Moscow, Russia.
  • Koneva ES; Group of companies «MEDSI¼, Otradnoe, Russia.
  • Kostenko AA; Sechenov First Moscow State Medical University, Moscow, Russia.
  • Bisheva DR; Group of companies «MEDSI¼, Otradnoe, Russia.
  • Sidyakina IV; Sechenov First Moscow State Medical University, Moscow, Russia.
  • Konev SM; Sechenov First Moscow State Medical University, Moscow, Russia.
  • Zhumanova EN; Group of companies «MEDSI¼, Otradnoe, Russia.
  • Illarionov VE; Sechenov First Moscow State Medical University, Moscow, Russia.
  • Shestakov AV; Group of companies «MEDSI¼, Otradnoe, Russia.
Vopr Kurortol Fizioter Lech Fiz Kult ; 99(4. Vyp. 2): 22-29, 2022.
Article in Russian | MEDLINE | ID: covidwho-2025845
ABSTRACT

OBJECTIVE:

To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19. MATERIAL AND

METHODS:

A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group (n=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group (n=18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group (n=16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire.

RESULTS:

All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day.

CONCLUSION:

Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ozone / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: Russian Journal: Vopr Kurortol Fizioter Lech Fiz Kult Year: 2022 Document Type: Article Affiliation country: Kurort20229904222

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ozone / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: Russian Journal: Vopr Kurortol Fizioter Lech Fiz Kult Year: 2022 Document Type: Article Affiliation country: Kurort20229904222