PHARMACOLOGICAL AGENTS WITH ANTIVIRAL ACTIVITY AGAINST CORONAVIRUS SARS-CoV-2

ABSTRACT

Data concerning the structure and reproduction of SARS-CoV-2 in human cells are presented and the possible targets for specific antiviral agents are considered. Some antiviral agents acting as inhibitors of RNA-dependent RNA-polymerase and main protease, and inhibitors of virus attachment and entry are discussed in view of their mechanism of action, activity in cell culture, animal experiments and their safety and effectiveness in clinical trials against COVID-19. © 2022 Izdatel'stvo Meditsina. All rights reserved.