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Inflammatory multisystem syndrome in COVID-19: Insights on off-target organ system in susceptible and recovering population
Stem Cells and COVID-19 ; : 47-57, 2022.
Article in English | Scopus | ID: covidwho-2027791
ABSTRACT
Coronavirus disease 2019 (COVID‐19) is an acute respiratory viral infection caused by SARS-CoV-2, an RNA virus. The first cluster of cases of COVID‐19 was reported from Wuhan, Hubei Province in China in December 2019. Soon after, the virus spread all over the world with 207 M confirmed cases, including 4.3 M deaths as of August 2021. Subsequently, the World Health Organization (WHO) declared the situation a public health emergency of international concern in January 2020 and later declared as a global pandemic threat. COVID‐19 mainly causes damage to the lung as well as other organs and systems such as the heart, the immune system, the nervous system, etc., and thus considered as a multisystem infection. Initial investigations provide insights about the pathogenesis of COVID‐19 and the role of ACE2 receptor has been elucidated. However, there is no complete treatment strategies proposed other than supportive care based on symptoms and severity. Though intense efforts are going on to vaccinate billions of people and at the time of writing 4462.8M vaccine doses have been administered, the pandemic continues spreading at a very fast rate. This chapter discusses the impact of COVID-19 in multisystem inflammation and multiorgan failure. Understanding the molecular and immunological aspects of this disease and diverse susceptibility in different patients would help to design better treatment methods in advance. COVID-19 is characterized by remarkable changes in the histology of multiple organs with high inflammation and necrosis. Along with that, the high imbalance in the immune system with abnormal secretion of proinflammatory cytokines and significant reduction in the circulating lymphocytes increases disease severity and organ damage. Addressing these scenarios carefully would help to discover blood markers or other analysis to predict the possible severity and chances of organ dysfunction in advance and design effective treatment. © 2022 Elsevier Inc. All rights reserved.
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Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Stem Cells and COVID-19 Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Stem Cells and COVID-19 Year: 2022 Document Type: Article