Mesenchymal stem cells: Novel avenues in combating COVID-19

ABSTRACT

From December 2019, COVID-19 pandemic has hit the human civilization in an unprecedented way. It has taken more than five million lives in just a span of two years. Two major mechanisms via which COVID-19 affects us are either via direct respiratory disorder and lung failure or otherwise via delayed flare of immune systems more prevalently known as the cytokine storm. Mesenchymal stem cells (MSCs) can be a potential therapeutic agent against mortality and morbidity of COVID-19 via direct differentiation into pulmonary epithelial cells as well as via antiinflammatory paracrine activities. MSCs are also can be useful to replicate COVID-19 infection in an in vitro organ model. In current study, we are systematically reviewing and finding out the potential applications of MSCs which could help mankind to combat COVID-19. © 2022 Elsevier Inc. All rights reserved.