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ATG4B hinders porcine epidemic diarrhea virus replication through interacting with TRAF3 and activating type-I IFN signaling.
Dong, Sujie; Kong, Ning; Qin, Wenzhen; Zhai, Huanjie; Zhai, Xueying; Yang, Xinyu; Ye, Chenqian; Ye, Manqing; Liu, Changlong; Yu, Lingxue; Zheng, Hao; Tong, Wu; Yu, Hai; Zhang, Wen; Li, Youwen; Tong, Guangzhi; Shan, Tongling.
  • Dong S; College of Animal Science, Tarim University, Xinjiang, China; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Kong N; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Qin W; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Zhai H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Zhai X; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Yang X; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Ye C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Ye M; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Liu C; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Yu L; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Zheng H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Tong W; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Yu H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Zhang W; School of Medicine, Jiangsu University, Zhenjiang, China.
  • Li Y; College of Animal Science, Tarim University, Xinjiang, China. Electronic address: lyw_lk@163.com.
  • Tong G; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China. Electronic address: gztong@shvri.ac.cn.
  • Shan T; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China. Electronic address: shantongling@shvri.ac.cn.
Vet Microbiol ; 273: 109544, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2028561
ABSTRACT
Autophagy-related 4B (ATG4B) is found to exert a vital function in viral replication, although the mechanism through which ATG4B activates type-I IFN signaling to hinder viral replication remains to be explained, so far. The current work revealed that ATG4B was downregulated in porcine epidemic diarrhea virus (PEDV)-infected LLC-PK1 cells. In addition, ATG4B overexpression inhibited PEDV replication in both Vero cells and LLC-PK1 cells. On the contrary, ATG4B knockdown facilitated PEDV replication. Moreover, ATG4B was observed to hinder PEDV replication by activating type-I IFN signaling. Further detailed analysis revealed that the ATG4B protein targeted and upregulated the TRAF3 protein to induce IFN expression via the TRAF3-pTBK1-pIRF3 pathway. The above data revealed a novel mechanism underlying the ATG4B-mediated viral restriction, thereby providing novel possibilities for preventing and controlling PEDV.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Coronavirus Infections / Porcine epidemic diarrhea virus Limits: Animals Language: English Journal: Vet Microbiol Year: 2022 Document Type: Article Affiliation country: J.vetmic.2022.109544

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Coronavirus Infections / Porcine epidemic diarrhea virus Limits: Animals Language: English Journal: Vet Microbiol Year: 2022 Document Type: Article Affiliation country: J.vetmic.2022.109544